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Variables
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Day 0
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Day 1
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Day 3
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Day 5
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Day 7
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|---|
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PELOD-2 score
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20 [15-22]
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16 [9.5-18]
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13 [9.0-18]
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10* [9.0-14]
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9.0* [8.0-14]
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VIS score
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15 [13-35]
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10 [6.0-17]
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9.0* [6.0-15]
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4.5 [2.5-17]
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3.0* [2.0-7.4]
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LMHW score
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10 [8.0-13]
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7.0* [5.5-8.5]
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7.0* [5.0-8.5]
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7.0* [4.0-7.0]
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6.0* [3.0-7.0]
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MAP
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1.0
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1.5* [1.1-1.8]
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1.2 [1.0-1.8]
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1.8* [1.5-2.0]
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1.6* [1.4-2.1]
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CVP
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1.0
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1.1 [0.8-1.8]
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1.0 [0.6-1.5]
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0.7* [0.4-1.1]
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0.6* [0.4-0.9]
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Urine volume
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(mL/kg/h)
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0.3 [0.2-0.5]
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0.1 [0.1-1.0]
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0.3 [0.1-0.4]
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0.2 [0.1-0.7]
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1.1 [0.1-1.8]
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Water balance
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(%)
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16 [14-24]
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3.7* [1.8-11]
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4.1* [1.6-8.8]
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3.1* [7.2-1.2]
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1.6* [3.3-0.5]
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TP
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(g/dL)
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4.5 [3.5-4.8]
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7.4* [6.8-8.1]
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6.9* [5.9-8.2]
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7.2* [6.4-7.8]
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7.3* [5.9-7.6]
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Lactate
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(mmol/L)
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7.3 [4.1-16]
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5.3 [3.6-10]
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4.1 [2.6-8.2]
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2.8* [1.5-4.8]
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1.8* [1.4-3.7]
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PLT
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(×104)
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4.6 [3.1-6.8]
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9.9* [6.6-16]
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11.7* [5.6-20]
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6.5 [5.6-114]
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12* [9.3-21]
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TAT
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(ng/mL)
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38.1 [24.4-450]
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89.6 [13.6-154]
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28.4 [10.8-77.0]
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19.4 [9.7-37.0]
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9.5 [5.6-20.0]
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PIC
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(pg/mL)
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3.6 [0.85-11.0]
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3.1 [0.58-6.2]
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8.8 [1.40-11.2]
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6.0 [2.5-16.6]
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4.9 [3.0-8.0]
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PAI-1
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(ng/mL)
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379 [174-1240]
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531 [372-848]
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322 [102-616]
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130 [27.7-173]
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34.2 [23.7-460]
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- Data are presented as median [interquartile range]. MAP and CVP are expressed as a ratio to the value at day 0
- PELOD-2 Pediatric Logistic Organ Dysfunction-2, VIS vasoactive inotropic score, JMHW Japanese Ministry of Health and Welfare, MAP mean arterial pressure, CVP central venous pressure, TP total protein, PLT platelet count, TAT thrombin–antithrombin complex, PIC plasmin α2–plasmin inhibitor complex, PAI-1 plasminogen activator inhibitor-1
- *p < 0.05 compared with before the treatment (day 0) by Kruskal–Wallis test and post hoc Steel tests
