Fig. 4
From: Effect of lactate as a peritoneal dialysis fluid buffer on rat peritoneal mesothelial cells
Effects of lactate on collagen genes. a Expressions of collagen type 1 mRNA for each stimulus time. b Expressions of collagen type 3 mRNA for each stimulus time 
control group, 
L5 group, 
L10 group, 
L20 group, 
L40 group, 
L80 group. **P < 0.01 vs control group. ***P < 0.001 vs control group. #P < 0.0001 vs control group. c Expression of collagen type 1 mRNA for each stimulus dose. d Expression of collagen type 3 mRNA for each stimulus dose: 
6 h, 
24 h, 
48 h, 
72 h. *P < 0.05 vs 6 h. **P < 0.01 vs 6 h. #P < 0.0001 vs 6 h. Increased expression of collagen type 1 mRNA was observed in dose- and time-dependent manners (a, c). Increased expression of collagen type 3 mRNA was observed upon stimulation with lactate at 40 and 80 mEq/L (b, d)