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| | |
Genotype
|
|---|
|
Variable
| |
CC
|
CT
|
TT
| |
|---|
| | |
(n = 23) 29.5 %
|
(n = 34) 43.6 %
|
(n = 21) 26.9 %
|
P value
|
|---|
|
Age
|
years
|
62.7 ± 6.9a
|
63.6 ± 8.7
|
63.2 ± 8.7
|
0.920
|
|
Gender(Male/Female)
|
n
|
11/12
|
10/29
|
10/11
|
0.261
|
|
Duration of hemodialysis
|
years
|
28.0 (25.0-31.0)b
|
31 (27.0-34.3)
|
32.0 (28.5-35.0)
|
0.276
|
|
Age at initiation of hemodialysis
|
years
|
33.0 ± 7.3
|
32.7 ± 8.5
|
31.3 ± 8.2
|
0.760
|
|
Height
|
cm
|
159.7 ± 9.1
|
155.7 ± 8.1
|
158.5 ± 7.5
|
0.170
|
|
Dry weight(DW)
|
kg
|
50.0d (43.8-59.5)
|
44.0e (39.1-50.9)
|
52.6d (44.5-59.3)
|
0.014*
|
|
Body mass index(BMI)
|
kg/m2
|
20.2 ± 19.7
|
18.8 ± 2.8
|
20.5 ± 2.6
|
0.050
|
|
BMI<18.5
|
n (%)
|
7 (21.9 %)c
|
19 (59.4 %)
|
6 (18.8 %)
| |
| 18.5≦BMI<25 |
n (%)
|
15 (35.7 %)
|
14(33.3 %)
|
13 (31.0 %)
| |
| 25≦BMI |
n (%)
|
1 (25.0 %)
|
1 (25.0 %)
|
2 (50.0 %)
| |
|
Bathel Index(BADL)
| |
90 (74-100)
|
98 (84-100)
|
85 (78-100)
|
0.253
|
|
BADL(independent/some help is necessary/with help)
|
n
|
20/2/1
|
33/1/0
|
18/1/2
|
<0.001*
|
|
Geriatric nutrition risk index(GNRI)
| |
9489-90
|
9088-96
|
9491-99
|
0.200
|
| ≧GNRI 91(without risk of malnutrition) |
n(%)
|
16 (34.8 %)
|
15 (32.6 %)
|
15 (32.6 %)
| |
|
<GNRI 91(with risk of malnutrition)
|
n(%)
|
7 (21.9 %)
|
19 (59.4 %)
|
6 (18.8 %)
| |
|
Biochemical parameter
| |
|
serum albumin (Alb)
|
g/dL
|
3.7 ± 0.3
|
3.8 ± 0.3
|
3.7 ± 0.3
|
0.887
|
|
total protein (TP)
|
g/dL
|
6.4d ± 0.3
|
6.6 ± 0.5
|
6.7e ± 0.5
|
0.045*
|
|
blood urea nitrogen (BUN)
|
mg/dL
|
63.8 ± 14
|
64.2 ± 6.6
|
67.6 ± 21.2
|
0.718
|
|
serum creatinine (Cr)
|
mg/dL
|
10.8 ± 2.3
|
10.5 ± 2.2
|
10.8 ± 2.2
|
0.873
|
|
urea acid (UA)
|
mg/dL
|
7.1 ± 1.3
|
6.9 ± 1.7
|
7.5 ± 1.5
|
0.341
|
|
serum sodium (Na)
|
mEq/L
|
141 ± 2
|
140 ± 2.6
|
140 ± 2.9
|
0.847
|
|
serum potassium (K)
|
mEq/L
|
5.1 ± 0.6
|
5.2 ± 0.7
|
5.1 ± 0.6
|
0.864
|
|
serum inorganic phosphorus (IP)
|
mg/dL
|
5.7 ± 1.1
|
5.1 ± 1.2
|
5.6 ± 1.8
|
0.164
|
|
serum calcium (Ca)
|
mg/dL
|
8.9 ± 0.7
|
9.3 ± 0.7
|
9 ± 0.6
|
0.096
|
|
Hemoglobin (Hb)
|
g/dL
|
10.4 (9.1-11.5)
|
10.3 (10.1-11.7)
|
10.2 (9.5-11.1)
|
0.789
|
|
Hematocrit (Ht)
|
%
|
33.5 ± 4.3
|
32.9 ± 3.3
|
32.7 ± 2.9
|
0.164
|
|
serum folate
|
ng/mL
|
4.7d (4.3-5.6)
|
4.7d (3.8-6.0)
|
3.9e (3.2-4.5)
|
0.005*
|
|
serum homocystein (Hcy)
|
μmol/L
|
30.5d (25.2-37.6)
|
25.1d (22.1-36.9)
|
35.4e (27.3-58.3)
|
0.029*
|
|
serum vitaminB12 (VB12)
|
pmol/L
|
545 (314-1200)
|
630 (383-1328)
|
456 (291-1463)
|
0.763
|
- Abbreviations: MTHFR Methylene tetrahydrofolate reductase, BMI body mass index, GNRI geriatric nutrition risk index, BADL Barthel index
-
aValues are means ± Standard deviation(all such values)
-
bValues are median(25th and 75th percentiles)(all such values)
-
cValues are number of all patients (%)
- The normality of the data was first assessed using the Shapiro-Wilks test
- The values are compared between the groups by the χ2 test, one-way analysis of variance and Tukey's multiple comparison test of or Games-Howell's test, and Kruskal-Wallis test and Bonferroni's multiple comparison test as appropriate. *p < 0.05
-
d-eMultiple comparison; A different alphabet shows that there is a significant difference
